Respuesta inmune en terneros experimentalmente infectados con diferentes dosis de Mycobacterium bovis

Recibido 18 de marzo de 2011 / Aceptado 21 de junio de 2011 / Publicado online 06 de julio de 2011

BLANCO, F.C. 1 ; BIANCO, M.V. 1 ; MEIKLE, V. 1 ; GARBACCIO, S. 2 ; VAGNONI, L. 1 ; CATALDI, A. A. 1 ; BIGI, F. 1

Resumen
La tuberculosis bovina es una enfermedad zoonótica producida por Mycobacterium bovis que afecta a animales de producción causando pérdidas económicas y representa, además, un problema para la salud pública. El conocimiento de la respuesta inmune inducida en el ganado bovino (el principal hospedador de M. bovis), durante la tuberculosis bovina es esencial para el desarrollo exitoso de medidas de control de la enfermedad. En este trabajo se determinó el perfil de respuesta celular que se desarrolla en terneros experimentalmente infectados con variadas dosis de M. bovis. Se observó que la respuesta celular CD4 es independiente de la dosis de inóculo, mientras que la respuesta celular CD8 es mínima cuando se infectan los animales a bajas dosis. También se observó que el nivel de producción de interferón gama (IFN-ɣ) por células monocíticas de sangre periférica no se asocia a la dosis de inóculo.

Abstract
Mycobacterium bovis, the causative agent of bovine tuberculosis, infects animals of agricultural importance and others mammals, including humans. Therefore, this disease causes significant economical losses and is a public health hazard. To better understand the immune response against M. bovis in cattle, in this study we characterized the immunological profile towards M. bovis antigens in cattle experimentally infected at various doses of a virulent M. bovis strain by measurement of IFN-ɣ production in peripheral blood mononuclear cells and by determining which lymphocyte subsets are involved in recall responses of peripheral blood mononuclear cells from infected cattle to M. bovis antigens. We found that the level of CD4 cell activation is similar among infected group irrespectively of the doses used to infect the animals, while activation of CD8 cells is dose-dependent. We also found that the production of IFN-ɣ in peripheral blood mononuclear cells after specific stimuli is not associated with the bacterial counts in the infectious doses.

Keywords: Bovine tuberculosis, Immune response, experimental infection, M.bovis.

1 Instituto de Biotecnología, CICVyA-INTA, N. Repetto y De los Reseros, 1686 Hurlingham, Buenos Aires, Argentina.
2 Instituto de Patobiología, CICVyA-INTA, N. Repetto y De los Reseros, 1686 Hurlingham, Buenos Aires, Argentina.

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